Ectoderm-Mesenchyme and Mesenchyme-Mesenchyme Interactions Regulate Msx-1 Expression and Cellular Differentiation in the Murine Limb Bud
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چکیده
منابع مشابه
Cyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content
Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore Cs...
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background: cyclosporine a (csa) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. many transplant recipients must take this medicine for the rest of their lives. females in reproductive age group on prolonged csa therapy have legitimate concerns about drug effects on pregnancy. objective: to explore ...
متن کاملHif-1α regulates differentiation of limb bud mesenchyme and joint development
Recent evidence suggests that low oxygen tension (hypoxia) may control fetal development and differentiation. A crucial mediator of the adaptive response of cells to hypoxia is the transcription factor Hif-1alpha. In this study, we provide evidence that mesenchymal condensations that give origin to endochondral bones are hypoxic during fetal development, and we demonstrate that Hif-1alpha is ex...
متن کاملInhibition of chondrogenic differentiation in chick limb-bud mesenchyme microcultures treated with cyclosporine
Objectives: To explore the effects of cyclosporine (CsA) on skeletal development (chondro genesis). Anatomy Department, Shiraz Materials and Methods: Mesenchymal cells obtained from stage-23 to stage-24 chickUniversity of Medical embryo limb buds were grown in 96-well plates using chemically defined tissue-culture Sciences, Shiraz, Iran. medium. Cultures were treated with CsA (0.01–5.0 μg/ml) ...
متن کاملFibroblast Growth Factor 4 Directs Gap Junction Expression in the Mesenchyme of the Vertebrate Limb Bud
Pattern in the developing limb depends on signaling by polarizing region mesenchyme cells, which are located at the posterior margin of the bud tip. Here we address the underlying cellular mechanisms. We show in the intact bud that connexin 43 (Cx43) and Cx32 gap junctions are at higher density between distal posterior mesenchyme cells at the tip of the bud than between either distal anterior o...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1995
ISSN: 0012-1606
DOI: 10.1006/dbio.1995.1087